Russia

December 21, 2020

We keep hearing about *the* vaccine, but of course, there’s more than one. Besides Pfizer, there’s Moderna… and we’ve all heard of some Chinese one and the Russian one which Putin gave his daughter but refuses to take himself.

Any others? Yes… plenty of others. This petal-to-the-metal race (locally) was won by Pfizer, if that’s how you want to look at it, and Moderna is set to come in second and Oxford-AstraZeneca will likely be third.

But really, there are multiple winners in this race… to win, you just have to cross the finish line. How many horses are in this race? Surprisingly… more than you might imagine. There were originally 90. Not all will finish the race, and while crossing the finish line counts, it’s probably a bit hollow if it happens in 5 years. However… the more, the merrier.

At present, Pfizer is approved and Moderna is approved for emergency use only (for the moment), but Canada is looking at it as we speak and it’s likely to get the green light within weeks. Beyond that, there are a few approved within China and Russia, but we’ll never see them here.

Beyond that, there are actually 18 different vaccines in phase-3 trials… most of them in the U.S and China, but other countries thrown into the mix and approaching the finish line are Japan, India and Australia. And Canada.

We don’t hear a lot about it, but we sure will if this gets beyond phase 3… Quebec-based Medicago, a private company, began their phase 2/3 trial on Nov 12th. In a somewhat eyebrow-raising arrangement, they’re being partially funded by cigarette maker Philip Morris. Medicago literally grows vaccines in plants – specifically, the Nicotiana Benthamiana plant, which is a wild species related to tobacco. The Canadian government has 76 million doses on order in case it all works out.

The fact you can grow vaccine inside tobacco raises some interesting possibilities, not the least of which is slanting the marketing towards “all natural” and “organic”. For all the anti-vaxxers with their “I don’t know what’s in it so I’m not putting it in my body!!!” crowd… notwithstanding I can assure you, you have no idea what’s in a McNugget but you’ll happily ingest that… but all that nonsense aside, hey… this vaccine grows out of the earth, in a plant that billions of people happily inhale into their lungs every day. The irony of that, given that this virus attacks your lungs…

You know, all of that is just one step away of creating a very unique vaccine delivery device… forget injections or suppositories or sublingual sugar cubes… how about…

“Hey dude, smoke up! This is some good shit!”

“Yeah man… whoah… where’d you get this?”

“Doctor B.”

“Who’s he? Never heard of him!”

“It’s a she… and don’t worry about it.”

“Awesome dude, can you hook me up with some more?”

“I can hook you up with one more; that’s all you need.”

“Whatever dude. Awesome.”

Vaccination rate… at least, in B.C….? 99.44%

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December 19, 2020

When I was in high school, we had a coach who employed a very unique form of punishment. When you screwed up, everyone had to run a lap around the field. And when I say field, it was actually four rugby fields… roughly a 600-metre jog for everyone. Well, almost everyone… you, the perpetrator, did not run. Just everyone else.

In fact, the first time that happened to me, I wanted to run too. I didn’t want everyone else even angrier at me. But no, that was the point.

“Sir, I’d like to run the lap as well.”

“No, Kemeny… you stand here with me and enjoy the consequences of your actions.”

The only thing missing was him providing some hot chocolate while I got to watch my friends and teammates being punished for my transgression. Just to really hammer home the point.

I mention this, because it’s interesting to note that collective punishment of this sort, where the said collective (friends, family, acquaintances, teammates, etc) is targeted, is a violation of the Geneva Conventions. It is literally a war crime.

If wearing the wrong jersey to rugby practice is so serious a crime that it warrants a punishment so severe that it’d require an international court to sort out, what do you do with a significant number of Republicans trying to overthrow the U.S. government?

The end-game of this election is starting to look like a horror-version of whack-a-mole… where there’s no cheap prize at the end, but that’s irrelevant… because the game never seems to end. You could argue it’s been going on for four years, but it’s certainly been going on since the election. After 46 days, those are some pretty tired arms. With still 32 days to go.

Every day, some nonsensical mole makes an appearance, and it’s swiftly whacked back into the hole by evidence, lack of evidence, a court ruling… or just plain common sense. And yet, the moles persist. The most recent mole to get whacked was Mitch McConnell, but that wasn’t enough. Now come some Republicans who literally want to overthrow democracy. Martial Law, and the whole thing.

Far beyond just cutting through the bullshit of Trump trying to pre-emptively pardon himself and his family, maybe it’s time for Joe Biden to make a much stronger statement. Number one, anyone who gets pardoned with some sort of cobbled-together Frankenpardon shouldn’t feel too safe. Those pardons will be rescinded within hours of the new administration, chopped up into little bits, just like the parts that came together to form this attempted monstrosity of legality.

And number two, anyone from this point forward trying to actively mess with the very foundation upon which American Democracy is based… will be charged. I don’t know if “attempted treason” is “a thing”, but it should be. Even if Biden gets tossed after four years, there needs to be something in place to prevent this derailing nonsense in the future… that those who instigate this sort of thing have some real consequences to face, not just running some laps in the dark, pouring rain.

But this is what the president is focusing on. This is what he’s re-Tweeting… while every single day, the new cases and deaths pile up. While some rogue nation, still not sure if it’s China or Russia, digitally broke in and stole everything. While a Covid relief bill still hasn’t wound its way through the process.

Allow me to quote Joe Biden: “C’mon, man.”

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By |2020-12-19T17:03:13-08:00December 19th, 2020|Categories: COVID-19 Daily Report, Politics|Tags: , , , , , , , , , , , |3 Comments

November 10, 2020

The KGB (today known as the FSB) is well-known for their “honey pot” traps. A foreign official shows up in Moscow and is treated to the finest food and the finest wine. And, through some clever social engineering, some of the finest women enter the picture as well… whose duty to Mother Russia is to seduce the target. This is all very-well thought out in advance, the who/what/where/when… which allows all of the activities to be secretly monitored and recorded. The victim is then told about (and possibly shown) the footage, and their cooperation is assured. Textbook blackmail.

But… it doesn’t always work out that way.

In 1945, Indonesia secured its independence from Dutch colonial rule. The first president they elected, a man by the name of Sukarno, fiercely loved his country. And women too, a fact that was well-known to the Soviets when Sukarno visited in 1960. It was quite a coincidence that a whole crew of attractive air hostesses was staying at the same hotel as Sukarno. Of course, it was no coincidence at all… and, of course, they weren’t actually stewardesses… they were all spies. Sukarno picked his favourites, and then, yadda yadda.

I wasn’t there to record the aftermath, but from what I gather, the conversation before the next day’s official meeting went something like this:

Soviets: “Mr. President, before we begin the negotiations, you should know that last night’s activities – all of them, including your time with Valentina and Natasha in your hotel room, were recorded on film. But as long as you…”

Sukarno: “What?! You filmed that? All of it? Like… everything…?!”

Soviets: “Yes, Mr. President… but if you…”

Sukarno: “AWESOME!! Hey, do you think you could score me a couple copies of that film!? They’re going to love this back home!! High five!!”

Sukarno thought he’d be a hero, going home with evidence he’d conquered some Russian beauties. The reception back home to his cavorting is not known, but given he had 9 wives throughout his life, many of the overlapping, it probably wasn’t a big deal.

In 2017, a British spy filed 17 intelligence reports, one of which outlined Donald Trump’s activities back in 2013 when he was in Moscow for the Miss Universe pageant. There is apparently a video, recorded in the Presidential Suite of the Ritz-Carlton… and nobody is too sure exactly what’s on the entire thing, but part of it is Trump watching two women urinating on the bed – the same bed in which the Obamas had previously slept.

These sorts of tapes rarely see the light of day. They’re very useful for “controlling the asset” while said asset is of any use. And once the asset is no longer relevant, there’s no point in disclosing it. In fact, there’s every reason not to… because it shows everyone around the world currently being blackmailed that as long as they play along, they’ll forever be ok.

That partially answers the question of “What do the Russians have on Trump?”… but it doesn’t really answer the question of “Now what?”

There is an emerging concern, and it’s a deep concern.

Trump knows a lot of state secrets. Given his treatment of the Russians over the last four years, it’s not hard to imagine they have something on him, and it’s pretty bad. And, he owes hundreds of millions of dollars. If you’re Putin, you’re holding the only winning trifecta ticket, where three longshots managed to come in 1-2-3. And now you’re pondering when and how to cash it in.

Let’s hope even Donald Trump, as low as he might stoop… and he’s stooped mighty low… would never reach those depths. Because if he did, this pandemic would be the least of the U.S. concerns.

HK COVID-19 Daily Report Graph for November 10, 2020

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September 6, 2020

There’s a virtual triangle that applies to many things in life… especially when it comes to actually creating or building something. Any project, really… and it’s a basic triangle where the three sides are labelled: Time, Quality and Cost.

Typically, you can pick any angle… and that’s what you’ll get; what those two sides offer – at the expense of the opposite side.

Want it quickly and cheaply? No problem, but don’t expect quality.
Want quality and want it soon? Sure, but be prepared to pay for it.
Want quality without spending too much? It can be done, but you’ll have to be patient.

It’s interesting trying to map this to the development of a vaccine. Everyone is throwing lots of money at it, so the only thing that’s sliding around is quality versus time.

On the one hand, you have a conglomerate of responsible companies who’ve signed a pledge not to rush anything to market until it’s ready, which means every step of a rigorous scientific process. Many of those are currently in phase 3… which is one step before early or limited approval.

On the other hand, you have President Trump promising a vaccine any day now, completely contradicting the head of Operation Warp Speed… and you also have a few places who’ve rushed a vaccine and knowingly are throwing it out there, having side-stepped phase 3, and/or doing it in unison. It’s also relevant that those places are Russian and China, where political statements and optics often outshine what’s in the best interests of the greater population. It’s pretty much the message that Trump is trying to shove down the throats of anyone who’ll listen, but it’s heartening to see scientists banding together in solidarity rebuking it.
The scientific world is well-aware what it takes to properly develop a safe vaccine. It’s a process. Like making a baby… that’s also a process. That one takes a man, a woman and nine months. You can’t throw nine men at it and hope to have the baby in a month. You can’t throw money at it. If you want to do it, there’s exactly one way to do it right, no matter what the president says.

And, fortunately, in the U.S. and Canada and many other places around the world, that’s what’s happening… there are presently 24 vaccine candidates in phase one, 14 in phase two and 9 in phase three. Many of them will probably hit the finish line around the same time. Getting them out there to everyone is a different issue, but first things first.

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Day 85 – June 9, 2020

My old high school calls me once a year… to sit on a sort-of Dragon’s Den panel thing… where all the students in business classes come up with business ideas and business plans, and the top 5 projects get presented to a panel of Dragons, much like the TV show of the same name. They do their business pitch, and the panel decides on the winner. Fun, interesting… and encouraging. There are some very bright, and soon-to-be successful kids coming down the pipe.

The winning pitch a few years ago was an App — ringtones that only young people could hear. Those higher frequencies, above 17.5KHz… most of us can hear them when we’re young… but by the time you hit 40, the ability goes away. The older you get, the farther down that number drops… below 15KHz and downwards. The presentation and demonstration were great; a bunch of blindfolded kids all putting their arms up in unison when the ringtone was activated; the rest of us unable to hear a thing. But the thing has other uses too — I used to use it to annoy my kids or get their attention. For those who can hear it, it’s loud and annoying, a super-high-pitched squeal that drives young people crazy. And nobody else can hear a thing.

It reminds me… a technology that didn’t exist when I was a kid… and has now cycled through to obsolescence… CDs, which were designed so that nobody would miss hearing a thing… 44.1KHz means 22,500Hz per stereo channel, more than enough frequency range for any human, and even more than enough for dogs to be able to hear that final note in “A Day in the Life”.

It’s also interesting that the standardized length of an audio CD, around 74-80 minutes (650-700MB)… was decided-upon because someone insisted that a full recording of Beethoven’s Ninth Symphony must be able to fit. Recordings of that Symphony range from 70 to 79 minutes, so it’s all good.

And what’s further interesting is that by the time Beethoven wrote that symphony, he’d already lost most of his hearing. It’s beyond comprehension… perhaps the greatest piece of music ever written… by someone who never actually heard it. There are many stories about the premiere of that piece, in 1824… where Beethoven himself insisted on conducting, the equivalent of a blind air-traffic controller armed only with binoculars and a megaphone. Nevertheless, it was Beethoven, so he was given the podium, and threw himself into the role with great relish. The musicians ignored him and kept their eyes on someone else, who quietly conducted from elsewhere. The result of that was… that by the time the piece was finished, Beethoven was still a few bars behind, caught up in the version playing through his head… and he was still conducting while the audience was giving him the first of five full enthusiastic, jubilant standing ovations. At some point, one of the musicians stood up and turned him around, so he could see and appreciate the well-deserved cheers and applause. He couldn’t hear it, but he could see it, including hats and handkerchiefs being thrown in the air, arms waving wildly around… the whole thing was a tremendous success.

Indeed, it’s possible to have great success, even when the conductor doesn’t know what’s going on. Even when all he’s listening to are voices in his head.

There are too many examples… heads of state… governors… Swedish head epidemiologists, etc… a long list of conductors that are out of sync with their respective orchestras… and this is where the metaphor breaks down, because there’s no other conductor off to the side. Because the music isn’t so great. While the varying orchestras may be marching to a different beat, at the end of the day, they sound like one voice. And what does that voice sound like? In many cases, it’s numbers… not notes. And not great numbers when you start looking around at places that haven’t managed things well, or that have started opening up before they should’ve. Yesterday saw surges or record highs in Oregon, California, Arkansas, Arizona, Texas, North Carolina, and Florida. Russia and India have seen surges. Also, Summer up here means Winter south of the equator. Brazil is a mess, and getting worse. Peru and Chile are seeing some pretty ugly numbers. Ugh.

Around here, some room for optimism… for Canada overall, over the last few weeks, a slow but steady decline in new cases. The Time To Double has gone from 53 days to around 130. Ontario’s TTD three weeks ago was around 39. Today it’s around 100. And both Quebec and B.C., over the last week, have averaged a TTD of around 175. All very far cries from the early days of this pandemic where TTDs of 3 were not uncommon.

Let’s just keep in mind… this symphony isn’t over. We may have reached the first pause, between the first and second movements. But let’s also remember the rules of classical music etiquette… you never applaud between movements. You wait until the whole thing is over before you stand up and give it the final applause of great success.

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Day 71 – May 26, 2020

There’s an interesting footnote about that Spanish Flu pandemic of 1918… which is the age distribution of deaths. For COVID-19, the median age of mortality is… well, it’s high. Depending where you look, it’s almost always north of 80. The younger you are, the better your chances… all the way down to zero, where except in extremely rare cases, often associated with other contributing factors, pretty-much anyone under the age of 20 looks safe from developing any serious symptoms.

A lesser-discussed pandemic is the Russian flu, which ran over a period of 4 years, peaking around 1890… and ultimately killing more than a million people worldwide. Its mortality profile is similar to COVID-19 in that it was far more dangerous for the elderly. But also, a big difference… is that it also killed a lot of very young people. The mortality rate for ages 0 to 10 was similar to those somewhere in the 40-60 range. The 10-30 age range was the least affected… and those over 70 were more than 20x likelier to die than that 10-30 group.

The 1918 pandemic hit the young people the hardest, a puzzling question that’s still being discussed, and there are very different ways of approaching it. The worst age to be for that pandemic was 28 — that was the highest-mortality age group. One common thought is that those who survived the 1890 pandemic built immunity, and were far less affected in 1918. But another interesting analysis starts with some simple math… 1918-28 = 1890. Indeed, those who survived the 1890 pandemic as infants… whether just born or perhaps still in utero — they were the ones hardest hit 28 years later.

To further confuse the issue, while it’s established that 1918 was without a doubt influenza (H1N1), there are some theories that 1890 wasn’t actually a flu, but a coronavirus… which obviously means that the theory of acquired immunity for older people can’t be correct, and that perhaps some drastic effect on the immune system of infants took place during a critical time of development.

Such are the sorts of things I learn when I fall into the Google spiral of doom… setting out to research something, and winding up very far away… and you all know how that can go… even here on Facebook, you log in to just send a quick message to a friend, and 20 minutes later you’re looking at wedding pictures of people you’ve never heard of.

What I started with today has to do with headlines like this:

“Coronavirus cluster linked to pool party” (Arkansas)
“Several members of a Franklin church test positive for COVID-19” (North Carolina)
“A second hairstylist potentially exposed 56 clients to COVID-19” (Missouri)

When I started writing this today, the American death count was below 100,000. As I prepare to hit [Post], it’s now over…

Some American states violently threw the doors open at the start of May — so now we’re seeing not just the initial effects, but the secondary ones as well. With an incubation period of 5 to 14 days, we’re perhaps even seeing the beginnings of a third. So how does it look… well, in 17 states, the numbers of new cases are trending upwards… among them Arkansas, North Carolina & Missouri. And Georgia. And Alabama. It’s really not a big surprise to see where things aren’t headed in the right direction. And there’s no reason to single out the U.S. — we’ve all seen those pictures from that park in Toronto a few days ago. I went for a great bike ride today, and my usual ride would have taken me down the Arbutus corridor, down to the water, and around the seawall… with a lap of Stanley Park if time (and regulations) permit. But I avoided all that, because I didn’t want to be anywhere near the sort of crowd I imagined I’d find.

The vast majority of people whose behaviour really makes you wonder… are younger. Because, you know, they’re invincible. And I don’t mean to single out an entire generation or two as irresponsible; it’s just what I happen to observe around me.

And when you think about it, I’m double their age and even I can’t really say I’ve suffered through any global health crisis that’s affected me. I’m old enough that certain vaccines didn’t exist when I was a kid, so I, along with most of my peers, suffered through chicken pox. The MMR vaccine showed up a few years after I was born, which means I missed the ideal window to have gotten vaccinated. I did, of course, as soon as it made sense… but anyone younger than me… they’ve largely been immune from birth… to diseases which, not that long ago, would’ve been affecting — and possibly claiming the lives of — friends all around them.

“The risks are for the history books and life is meant to be lived and we’re not really at risk, etc etc.”

It’s not a great attitude, in general… and it applies to everyone who thinks for some reason we’ve made it free and clear to the other side. We haven’t, yet. Opening up doesn’t mean throwing caution into the wind.

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Day 70 – May 25, 2020

Yesterday’s post was met with a wide range of reaction, and the questions and comments lead me to think a bit of clarification and more detail would be appropriate. Some of those comments came from Swedes themselves, a little bit upset at being painted somewhat ruthlessly; to clarify, I’m speaking about leadership and their policies; not the general population, many of whom don’t agree with the official policy in the first place. And to also clarify, I’m not implying their leadership and epidemiologists are evil. They simply came up with a strategy, and it’s not working as they’d hoped. So, här är del två…

I first wrote about Sweden on April 10th… more than 6 weeks ago. I welcome you to scroll down and find it — it’s a pretty good summary of where things stood at that point, what measures where (and weren’t) in place, and what I thought of the whole idea. And sure, “What do you know?” is a fair question to ask of me… especially 6 weeks ago. We’re all continually asking the question of each other, and hopefully learning something. That same article also mentions a famous letter signed by more than 2,000 Swedish doctors, scientists and professors… the contents of which can be summarized succinctly as it relates to government policy (which hasn’t changed): “They are leading us to catastrophe”.

First of all, let’s clarify exactly what is meant by herd immunity.

Herd immunity is where enough people of a population are immune to the extent that the infection will no longer spread within that group. The more infectious a disease, the higher that percentage has to be. For example, mumps is very contagious. It has an Rø of 10 to 12, meaning every infected person will infect, on average, 10 to 12 others. Left unchecked, this would lead to 95% of the population getting infected. After that, the population can be considered to have acquired herd immunity, and the other 5% will inherit the benefit of that… because at that point, there’s no one left to catch it from. Measles has similar numbers. That particular herd-immunity threshold is very high, and can only be reached via vaccination because allowing everyone to catch either of those horrible diseases is not an option. And these days, completely preventable.

With the way the math works, the higher the Rø, the higher that herd immunity threshold. For COVID-19, estimates seem to run between 1.4 and 3.9. Both of those numbers seem extreme, but for the record, they imply a range of 29-74% to achieve herd immunity. An Rø of 2.3 seems to be generally accepted, implying herd immunity could be achieved with 57% of the population having become infected.

Is that likely in Sweden? Anywhere?

Before we answer that, it’s worth noting that the policy-makers in charge in Sweden have been backing away from claiming this was the idea in the first place. It’s a mixed message for sure, and it’s changed over time. I think it’s reasonable to assume it was the original intent; shelter those most at risk (an impossible task, but that’s also a different discussion) and then let the virus do as it may. But, to confuse things a bit, while businesses were to be open, a vast number of Swedes, not too different from Americans in some confused places, said to hell with what the government tells us; we will take our lead from others, perhaps like those 2,000 who signed that letter.

That’s intelligent on their part, but certainly affects the plan of “get the virus out there”. You can’t have it both ways, and perhaps you end up in a purgatory of sorts… where there’s too much illness to be handled properly, but nowhere near enough to be even close to establishing herd immunity. Indeed, by an order of magnitude, nobody on the planet is even remotely close. What do we need? 70% 60%? I’ll give you 50%. What’s Sweden at? Maybe 9%. More likely closer to 7%. And let me clarify… I am in no way blaming Swedish society for not doing their part; I’d have done the same thing, isolating myself and not frequenting crowded places. Even without any sort of lockdown, achieving herd immunity was not going to happen. Even if it were possible, it’d take years. To be sure, there are a lot more people who’ve been infected than we know… but still… that Stanford study that implied infection rates 50 to 85 times higher than thought… there are problems with that study, but let’s take it at face value… where are we at with that, near San Francicso? 2%. Nobody is even close to herd immunity, and it’s likely nobody will get there. Of course, a vaccine achieves that instantly, and that’s why we’re diligently aiming in that direction.

That sad thing about Sweden is that they could’ve seen it coming, but did nothing to prevent it. The U.K. tried this strategy… shelter the weak, keep things open, weather the storm… and bailed on it around March 17th. The U.K. was only at around 2,000 cases, but it was the drastic nature of growth that led them to quickly understand how bad this could get. Sweden had seen its 1,000th case by then, but it wouldn’t have been too late to re-evaluate then. Or the next day. Or any of the 40+ days since.

There is a discernible and not-too-surprising pattern emerging around the world; here are the worst three countries… for total cases, and daily new cases. In other words, not only have they seen the most cases, but they’re all still growing — faster than anyone else: U.S., Brazil, Russia. What do they have in common? Here’s a hint: Trump, Bolsonaro, Putin. Try changing those minds.

The Prime Minister of Sweden, Stefan Löfven, is no renegade populist. He’s a social democrat. And he’s dealing with a population of only 10 million people. It’s not great now, but it’s not too late. I wrote recently about the joys of being wrong, and the opportunities it affords. Perhaps it’s time for Sweden to give it some thought.

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