Research

Day 71 – May 26, 2020

There’s an interesting footnote about that Spanish Flu pandemic of 1918… which is the age distribution of deaths. For COVID-19, the median age of mortality is… well, it’s high. Depending where you look, it’s almost always north of 80. The younger you are, the better your chances… all the way down to zero, where except in extremely rare cases, often associated with other contributing factors, pretty-much anyone under the age of 20 looks safe from developing any serious symptoms.

A lesser-discussed pandemic is the Russian flu, which ran over a period of 4 years, peaking around 1890… and ultimately killing more than a million people worldwide. Its mortality profile is similar to COVID-19 in that it was far more dangerous for the elderly. But also, a big difference… is that it also killed a lot of very young people. The mortality rate for ages 0 to 10 was similar to those somewhere in the 40-60 range. The 10-30 age range was the least affected… and those over 70 were more than 20x likelier to die than that 10-30 group.

The 1918 pandemic hit the young people the hardest, a puzzling question that’s still being discussed, and there are very different ways of approaching it. The worst age to be for that pandemic was 28 — that was the highest-mortality age group. One common thought is that those who survived the 1890 pandemic built immunity, and were far less affected in 1918. But another interesting analysis starts with some simple math… 1918-28 = 1890. Indeed, those who survived the 1890 pandemic as infants… whether just born or perhaps still in utero — they were the ones hardest hit 28 years later.

To further confuse the issue, while it’s established that 1918 was without a doubt influenza (H1N1), there are some theories that 1890 wasn’t actually a flu, but a coronavirus… which obviously means that the theory of acquired immunity for older people can’t be correct, and that perhaps some drastic effect on the immune system of infants took place during a critical time of development.

Such are the sorts of things I learn when I fall into the Google spiral of doom… setting out to research something, and winding up very far away… and you all know how that can go… even here on Facebook, you log in to just send a quick message to a friend, and 20 minutes later you’re looking at wedding pictures of people you’ve never heard of.

What I started with today has to do with headlines like this:

“Coronavirus cluster linked to pool party” (Arkansas)
“Several members of a Franklin church test positive for COVID-19” (North Carolina)
“A second hairstylist potentially exposed 56 clients to COVID-19” (Missouri)

When I started writing this today, the American death count was below 100,000. As I prepare to hit [Post], it’s now over…

Some American states violently threw the doors open at the start of May — so now we’re seeing not just the initial effects, but the secondary ones as well. With an incubation period of 5 to 14 days, we’re perhaps even seeing the beginnings of a third. So how does it look… well, in 17 states, the numbers of new cases are trending upwards… among them Arkansas, North Carolina & Missouri. And Georgia. And Alabama. It’s really not a big surprise to see where things aren’t headed in the right direction. And there’s no reason to single out the U.S. — we’ve all seen those pictures from that park in Toronto a few days ago. I went for a great bike ride today, and my usual ride would have taken me down the Arbutus corridor, down to the water, and around the seawall… with a lap of Stanley Park if time (and regulations) permit. But I avoided all that, because I didn’t want to be anywhere near the sort of crowd I imagined I’d find.

The vast majority of people whose behaviour really makes you wonder… are younger. Because, you know, they’re invincible. And I don’t mean to single out an entire generation or two as irresponsible; it’s just what I happen to observe around me.

And when you think about it, I’m double their age and even I can’t really say I’ve suffered through any global health crisis that’s affected me. I’m old enough that certain vaccines didn’t exist when I was a kid, so I, along with most of my peers, suffered through chicken pox. The MMR vaccine showed up a few years after I was born, which means I missed the ideal window to have gotten vaccinated. I did, of course, as soon as it made sense… but anyone younger than me… they’ve largely been immune from birth… to diseases which, not that long ago, would’ve been affecting — and possibly claiming the lives of — friends all around them.

“The risks are for the history books and life is meant to be lived and we’re not really at risk, etc etc.”

It’s not a great attitude, in general… and it applies to everyone who thinks for some reason we’ve made it free and clear to the other side. We haven’t, yet. Opening up doesn’t mean throwing caution into the wind.

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Day 67 – May 22, 2020

During high school, I came to the realization that there are two basic ways of learning. One is simply memorization. The other is actually understanding the subject matter and being able to apply it in a more generalized form, mappable to new situations. Some people are good at both. I’m really only good at the latter. And I suppose some people… neither.

Imagine someone who is awful at math, but memorizes the times-tables all the way to 99. You can ask them 73 x 96, and they know 7,008 instantly. But ask them 2 x 100 and they have no clue. Do they really know the subject matter? I worked with a lady once who told me how she’d missed the day they’d learned the seven-times-tables.

“Really? What’s 7×3?”
“I don’t know.”
“What about 3×7?”
“Oh, that’s easy. 21”
“Yeah… but… ok, what about 7×8?”
“I don’t know!”
“But 8×7…”
“56”
“You realize that if you just flip the numbers around, it’s the same… like 7 times anything is always the same as that anything times 7.”
“…. oh. OK, sure”.

I’m sure she didn’t quite get it, but kudos to her for finding a way to “learn” something, using the tools at her disposal. But that’s kind of the thing. I’m not sure how useful those sorts of math skills can possible be if you don’t really understand. Many animals can be trained memorize something, but it doesn’t mean they understand it.

Here’s a neat trick for you… quick, what’s 8% of 50? If that has you thinking for more than 2 seconds… flip it. What’s 50% of 8? That works for any percentage. You’re welcome.

One time, in grade 10, we had to memorize some Shakespeare. It was a long passage from Julius Caesar that starts with “I cannot tell what you and other men think of this life, but for my single self…. yadda yadda…” It goes on for a long time, and I struggled for 2 whole days trying to memorize it. I am genuinely in awe of Shakespearean actors… I honestly think it’d take a lifetime to memorize an entire play. The thing is though, once I “know” it, I know it forever. That long passage I just described, I guess you could say I “learned” it, as opposed to photographically memorized it. I still know every word of it, decades later, a parlour trick I’m happy to trot out on occasion… and it’s impressive how long it goes on. Usually till someone finally says, “Yeah, yeah… we get it.”

That passage was assigned on a Monday, for a Wednesday class where the test was simple: walk in and write out the passage. It will be marked out of 50, and every spelling or capitalization or formatting error will cost one point. We had to memorize not just the words, but their presentation. Like I said, I struggled tremendously. Memorizing anything is hard enough, but Shakespearean English? if 't be true thee bethink mem'rizing mod'rn english is sore, what doth thee bethink about this confusing mess?

English was the second class of the day. As we left math class on our way to write this test, I was walking with a friend, and reading through the whole thing again, for probably the 2,000th time. I asked him…

“So, you ready for this?”
“Ready for what?”
“This Shakespeare thing, did you memorize it ok?”
“Oh, shit! That’s today?”
“Uhhhh… it’s now.”
“Here, give me the book.”

It was a 3-classroom walk from math to english, during which time he scanned the text 3 or 4 times.

“OK, got it.”
“You’re kidding.”
“Yeah, no problem.”

We walked in and we wrote the thing. After school, I asked him how he did.
“Aced it”, he said.
Sure, I thought. And he also told me that 15 minutes after the class, he’d already forgotten the whole thing.

When we got it back a couple of days later, he got 50/50… 100%. It was perfect. I got 30/50 — 60%. I had mis-spelled some words, missed some capital letters, missed some punctuation and put some in where it didn’t belong. It was like every single line had one little thing wrong with it. All of those mistakes I would consider irrelevant, if you’re trying to capture he actual meaning, the actual spirit of the thing. What exactly was learned in that scenario? My friend didn’t learn anything. He just got to flaunt his photographic memory. I don’t call what I retained any sort of useful “learning”.

That high-school experience also provided two very different types of history teachers. One of the classes was all about taking notes, literally transcribing what the teacher said and regurgitating it during tests. Exact dates, times and places. The other one was about understanding what was happening, and what led to what, and how certain events affected future events. The tests were all about expressing opinion on historical events, not asking what date they happened. You can guess in which of those two classes I did better.

At the end of the day, everyone has a different way of learning… of capturing information, analyzing it and storing it. I’m usually not interested in learning anything that doesn’t involve some element of understanding… but, sometimes, you don’t need to actually understand it; just memorize it. Masks, good. Crowds, bad. Social-distancing, good. Enclosed spaces, bad. Outdoors, good. Hydroxychloroquine, bad. Etc, etc.

On it goes. For those who like learning about things, this pandemic has been offering ample opportunity. Endless, evolving research. Feel free to dive in, if you feel so inclined. And if you don’t, that’s ok too — just memorize the important stuff.

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Day 64 – May 19, 2020

These little walks down memory lane, like yesterday’s piece on Mt. St. Helens, always seem to stir up something else… that I likely haven’t thought of in ages. Indeed, yesterday’s piece started off about a Sunday morning, with me describing how I was just sitting there reading… and nobody has asked me what I was reading, but I will tell you anyway… it was the stock-exchange listings from the previous night’s Vancouver Sun. And if you’re wondering why is an 11-year-old kid was reading stock prices on a Sunday morning 40 years ago, I’ll tell you…

Our grade-6 teacher had created a very cool one-month project. We would all get to buy and sell stocks, all starting with a virtual $1,000, and he would track it on a big chart in the classroom. Every day, we would submit our “trades” — buy this many shares at this price, sell this many at that price. He would do the math and track everyone’s profit/loss. We would submit our trades every morning, along with where we’d gotten the price — The Vancouver Sun or The Province.

There wasn’t really much research that could be done on it… at best, you’d have day-old news to contemplate, and anyway, we were in grade 6… who’s doing any sort of real research, and even if we did, to what end… whatever we might come up with would already have been built into the stock price. But it was a fun exercise, and of course, it grew very competitive, watching everyone’s graph-lines wiggle up and down from day to day. For the most part, people were picking stocks by names that sounded good, or maybe familiar. By the end of two weeks, a few lines had started to separate upwards… and I wasn’t one of them, and it was bothering me. And it didn’t seem like lucky guesses. These guys knew something.

As it turns out, indeed they did; their fathers were stock-brokers or somehow involved in business where they had access to better information. My dad was a mining engineer, so at best he suggested a few mining companies that were exploring for gold… but they weren’t going anywhere in a hurry. I needed to find an edge.

Arbitrage is the simultaneous purchasing and selling of an asset, where the buy price is lower than the sell price, so the transaction generates an instant and risk-free positive return. The most common place where this takes place is financial markets, where, for example, a certain stock may be listed on multiple exchanges. If you have instant access to both markets and notice that shares of ABC are offered for $10⅛ on one and being bid at $10⅜ on another, you buy the cheap one, sell the expensive one, and deliver the cheap ones to the guy that bought the expensive ones. This all happens instantly, and while making ¼ on that transaction may not sound like much, it certainly adds up when you do it 1,000 shares at a time, multiple times a day. There are armies of supercomputers trying to do this continually, all day these days, and to some extent, that serves a useful purpose… it keeps prices in check. As soon as an opportunity arises, some arb grabs it instantly, and the advantage is gone.

And what I had stumbled upon a few days earlier was this… perhaps an opportunity for manual arbitrage, though at the time, I did’t even know that word… all I knew was that, on the same day, the prices listed in The Vancouver Sun were different than The Province. Why?

As it turned out… The Sun was an afternoon paper… it’d always show up around 5pm. The Province was an early-morning paper, always there by breakfast. In our home, we got both. And here was the thing…. by the time The Sun needed to go to print to make it for afternoon deliveries, the stock markets weren’t closed yet. The price listed in The Sun was the day’s mid-morning price, taken at… 11am? Noon? Not sure, but certainly well-before the 1:30pm market close. The Province the next morning had the closing prices from the previous day… and so, differences in price. And by scouring for prices that were higher in The Province, I could “buy” them with yesterday’s lower price and hope the upswing held long enough that I could “sell” them at a higher price. Not all stocks that went up in that last hour of trading stayed up, all through the next day, in time to sell them… but something like 80% of them did, which is staggeringly-high, well-beyond any typical financial wizardry from even the best analysts.

My wiggly line started heading north pretty quickly after that, much like the Mt. St. Helens ash plume… and with almost as much vertical force. Within a week, I’d caught up to the competition…. and just kept rolling… which led to the teacher asking me to stay after school that next Friday. “OK, what’s going on here?”, he asked. Of course, I couldn’t keep my mouth shut… I was so proud of being so clever and figuring out this loophole. I spilled everything. “Do you think that’s fair?”, he asked me… and my simple question back was, “Is it against the rules?”

From there, we had an interesting discussion about The Rules vs. The Spirit Of The Rules. What rules? The stock market is a game where you’re trying to win, and to win, you have to out-think someone else. Where in the rules does it say I can’t do this? Yes, I realize this isn’t possible in reality, but this is not real. It’s a game, and I found a better way to play it.

And after that, although I think he was impressed by my resourcefulness, he changed the rules. All trades must be submitted in the morning, using that morning’s quotes from The Province. End of advantage, and I ended up losing because one of those other guys sold everything, and put it all onto one particular stock which shot up on the very last day. Because asking daddy for inside information is ok, but figuring out how to play the game better… is not. Yes, I’m still bitter.

So… there are rules.… some rules, archaic and irrelevant, are meant to be broken. Some rules, for the greater good, need to be adhered to. Then… there’s that grey area of bending rules. Today, here in B.C., the rules have changed. We have had rules in place for more than a couple of months, and they have served us well. So well, that many people will insist we never needed them, and that is very wrong. Either way, as of today, with our rule changes, it’s one step forward towards a return to normal.

On the assumption that the people who make these rules know what they’re talking about — and, given their success, they certainly do — we should follow them. Indeed, our local rules and implementation thereof have become a model not just for Canada or North America, but the entire world. For populations of 5 million plus, we are number one. I would really love to see us stay there. Some people will break those rules. Some people will bend them… but I suggest, let’s try to stick to them. And if you think you can’t stick to the rules, at least consider the spirit of the rules. It’s not just about you. The stakes are a lot higher than those wiggly lines on a large paper chart from 40 years ago. Look at the wiggly lines on the charts attached to this post, especially the yellow one. Especially today. That is success. That is a win. Let’s all do our part to keep it there. Let’s keep rolling.

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Day 49 – May 4, 2020

Consider this sentence: Over 20% of people tested positive.
Now consider this one: Only 20% of people tested positive.

Without even knowing what we’re talking about… without even knowing if testing positive is a good thing or a bad thing… like, perhaps we’re talking about infections. Perhaps we’re talking about antibodies. Perhaps we’re talking about random drug testing in your office. Perhaps we’re talking about cyclists and performance-enhancing drugs. Perhaps we’re talking about asking random people on the street what their outlook is for the future.

We don’t yet have a clue what we’re talking about, but the very first word of that sentence is already guiding your thought process. Better stated, the writer of that sentence (that’d be me) knows what he wants you to think, and is subtly suggesting it. I want you to agree with me. Maybe I want you to think that anything under 20% is fine. Or maybe I want you to think that anything over 20% is bad. But wait a minute, what if testing positive is a good thing? Then it’s the other way around.

Let’s take out those first words… what are you left with…. “20% of people tested positive”

OoOoOohhh, now what. What are you supposed to do with that? Think for yourself and decide?! Indeed, the vast majority of content we consume these days is written more towards getting you to think a certain way, or agree with a certain viewpoint — than to simply present the information. And further to that, once the algorithms have figured out what you like to think/read, they’ll spoon-feed you those sorts of stories… mostly because they know you’ll click on them, and that’ll generate ad revenue for them. This has pretty-much nothing do to with conveying news.

Back in the late 80s and early 90s, I did work for what was, at the time, the largest multi-line BBS west of Ontario. A BBS is an electronic Bulletin Board System, where you could call in with your computer’s modem and read/post public or private messages and play games and download a variety of different things. The vast majority of BBSs were single-line systems operated by hobbyists, but a few managed to take the technological leap to allow more than one person online at a time, no small feat as it required a lot of computing power, complicated software, multiple modems and multiple phone lines. From there arose chat systems and multi-player games.

This particular BBS, Mind Link, grew from 4 to 8 to 16 to around 40 phone lines by 1994, at which time it was acquired in the first wave of consolidation leading to what is today, the Internet. Indeed, Mind Link was one of the first in all of Canada to be able to offer an on-ramp onto that emerging information superhighway. It was all text-based back then, and it took about 10 finicky steps of loading unstable software in just the right sequence, just to get online. It was a virtual building of a delicate house of cards, every time. One wrong move and it would all lock up. In fact, it often locked-up for no reason at all.

I loved that job, for numerous reasons. First of all, the staff, all wonderful people, all intelligent and bright and some as tech-geeky as myself. And, I got to play with the coolest technology around; I was there the day we switched on the pipe to the internet — four Telebit Trailblazer modems working in sync, achieving a combined bandwidth of about 75 Kbps. Your internet connection today is somewhere between 20,000 and 1,000,000 Kbps. But back then, state of the art. Leading edge. Bleeding edge.

Part of my job was keeping it all going, a jack of all trades fixing whatever problem came up, known or obscure. And part of what I kept going were the news feeds. Back then, Mind Link contracted to receive news from a guy called Brad Templeton. His company was called ClariNet, and it was possibly the very first dot com to ever exist, because before that, commercial use of the internet was prohibited. Brad was a cool guy, and I spoke to him on a few occasions… and one time, the discussion drifted to the commercialization of the Internet, something most of its users (me included) did not want. What the heck is a dot com? There were dot org (non-profit organizations), dot edu (educational), dot gov (government) — but dot com? Commercial enterprise? Forget that. “It’s coming”, he said, “Prepare yourself. There’s opportunity here.” And I remember telling him, “Forget it. We won’t let that happen.” I told that quote to a few friends at the time, and they still won’t stop teasing me about it.

ClariNet dot com was allowed to exist because Brad cleverly convinced the powers that be that news is indeed an educational resource, and it would make sense to distribute it with the existing infrastructure. That he was doing it for profit was a secondary point, because what Brad was doing was very useful… he was consolidating news feeds straight off the wire… from UPI (United Press International), AP (Associated Press) and Reuters. These are the wire services where all news outlets get their news (or should, at least). Here was an unfiltered, raw source of news, straight from the ground. No editor, no opinion, just the facts. Twenty precent tested positive. No “Over”. No “Only”.

Part of what I did was make sure that the ClariNet feed was working properly, and that Mind Link was properly taking the news from those three sources and parsing and indexing everything into the right newsgroups. So, yes — I ended up reading an awful lot of news, and it led to a great appreciation of those particular three sources. I still look to them today for raw news, unfiltered by bias or opinion.

upi dot com
reuters dot com
ap dot org

In my opinion, far better than much of what’s out there.

So, on that note… acting as a news wire today, I will pass along four items of relatively unfiltered news, all of them interesting in their own way.

First… South Korea today is now reporting that those 263 patients who initially had been thought to have been re-infected — weren’t. Those people had re-tested positive after having been cleared of the virus, and it had been thought they may have become re-infected. However, none of those people developed symptoms again, and they’re now saying what many others around the world were saying… it must be a testing issue. Yes… the tests were picking up dead remnant virus fragments, not new infections. It might take months for the body to clear itself of dead virus fragments, but as of yet, there has not been a single case where those fragments have sprung back to life, nor is there any evidence of anyone who’s ever had the virus catching it a second time.

Second… an interesting story developing out of France. Something like 25% of French people smoke… but of the almost 500 COVID-19 patients admitted to a certain Paris hospital, only 5% were smokers. That is statistically significant, implying smokers are less likely to catch this disease. This is so counter-intuitive, it begs a closer look… and what’s emerging from the research is this: There is a cell-membrane protein called ACE2 which the COVID-19 virus attaches to, in order to infiltrate a healthy cell. But nicotine also binds to ACE2, leaving less of an opportunity for the virus to do so. And nicotine is also known to decrease inflammation. I would strongly urge you… do not take up smoking to protect yourself from this disease… but if you’re a recovering smoker and presently on nicotine patches or gum — that might be doing you more good than you think. France is preparing a trial of providing nicotine patches to patients, front-line workers and ordinary citizens. We shall see.

Third… an as-of-yet-not-peer-reviewed-but-still-interesting study… in a small sample group of ICU patients suffering from serious complications of this disease, in a group of patients aged less than 75… 100% — yes, all of them — were found to be Vitamin D deficient. That’s also eyebrow-raising, and it’s one you can very easily manage. Vitamin D supplements are available everywhere, and they’re cheap… and, it’s pretty difficult to OD on Vitamin D. There does exist such a thing as Vitamin toxicity, but you have to go way overboard to get there. Recommended doses range between 500 and 5,000 IU a day. I take 2,000. Apparently, you can go up to 10,000 a day for long periods of time and not suffer any consequences, but one might add that perhaps an optimal range is what’s desired; too much may also be harmful and it should be noted that Vitamin D, unlike Vitamin C, is not water-soluble. It’s fat-soluble, so your body will store it. But then again, you really have to go insane to over-do it… like 40,000 to 100,000 IU daily for months, before it becomes toxic. And/or, of course, just listen to Dr. Henry — go outside to the glorious wonderful sunshine for 30 minutes a day… it’s good for you in more ways than you might imagine.

Finally… green numbers all across Canada today. TTD numbers approaching 4 weeks or more… everywhere.

Extra extra, read all about it… good news all around.

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Day 46 – May 1, 2020

One Saturday morning in the Summer of 1982, I hopped on a couple of buses and made my way to the Robson Square Media Centre, which at the time was the city’s busiest (and perhaps only) place where conventions were held, located around the perimeter of the skating rink, now part of UBC.

I was there because there was a computer convention going on… one of these pioneer computer shows, long before the rise (and fall) of Comdex.

I went around checking out the cool technology of the day, and gravitated towards a few booths with familiar names. One of them was Microsoft, and I got to chatting with a guy who didn’t look too much older than me, some geeky skinny teenager with whom a I had a great chat about the newly-released Microsoft Flight Simulator… a game which I was a huge fan of, and continue to be. I’m sure if the hours spent on MS FlightSim counted towards real pilot hours, I’d be qualified to fly a 747 by now. I had no idea about that company’s corporate structure or who this guy might be; I just appreciated that somebody “official” with the company found time to chat with this pesky little kid, and listen to his thousand questions and suggestions. Nice guy, whoever he was (his name-tag said “Bill”). A year or two later, I realized who that had been.

Sixteen years later, I was sitting at a $1/$2 limit hold’em table in The Mirage poker room in Las Vegas when the PA system paged “Bill for one-two, Bill for one-two”. And shortly after that, Bill Gates sat down a few seats away from me with a few hundred dollars in chips, just like any other regular Joe. And for the most part, he was treated as such; just one more person trying to play his game. I said “nice hand” to him at some point, after he outplayed me and took some of my money. But that was the extent of my interaction with him, and that was the last time I saw him in person.

My definition of knowing someone might be: When you bump into them on the street (6 feet apart these days!) and you both know each other. There are problems with that definition, because sometimes one person knows the other, but not the other way around. More than once, somebody has come up to me like they’ve known me all their lives with a huge hello, how are you, what’s new, how’s work, etc etc. And I have no idea who they are. They look familiar, sort of… maybe? Awkward. More awkward is when both of you know that you should know each other — and probably you do, from somewhere… but neither is sure…. “Oh yeah, hey… how are you? …how’s… uhhh… the family, yeah the kids, how are the kids, gosh they must be getting so big by now, how old are they? Oh yeah wow, how time flies, hey we should get together and have lunch or something… yeah, for sure, have your people call my people and set something up, haha. Yeah, cool, seeya”….. ok, who the hell was that… Super Awkward.

And actually, I guess that two very famous people who’ve never met could bump into each other on the street and know exactly who the other is, but they don’t actually know each other.

Anyway, by any definition, I don’t know Bill Gates… but I’ve been following what he’s been up to for most of my life… he’s gone from the guy who co-founded Microsoft to the guy who ran Microsoft to the guy who stepped back from running Microsoft to the guy who retired entirely from Microsoft, to pursue other things. And one of the things he’s pursued is the foundation he set up, along with his wife.

The Bill & Melinda Gates Foundation is involved in sorts of things, many of them hugely ambitious — the sort of thing that requires teams of supremely qualified people, and billions of dollars. Thanks to his life’s work and success, he’s able to provide both… and seeks to tackle things on a global scale: education, health, poverty, access to information and technology. For everyone.

Among his epic pursuits: he seeks to eradicate polio, he pours money into HIV research and treatment and he provides vaccinations for poverty-stricken countries. Thanks to him, deaths from measles in Africa are down 90% in the last 20 years.

So when Bill Gates starts talking about a potential vaccine, it’s worth listening, and he’s had a lot to say. Some of the highlights include his explanation on how a process that can typically take 5 years could be compressed into just 18 months, by overlapping parts of the process that typically would be done sequentially. For example, instead of waiting for a confirmed, tested and approved vaccine before mass-manufacturing, why not scale up the production of it while tests are still ongoing? At worst, it’s not good, and you just throw all that away… but if it works out, you’ve saved months or even years. There’s a cost to that, of course — throwing money at a problem sometimes means throwing the money away, but sometimes money can buy time, and this is one time where we all agree it’s worth it. And where would that money come from? Bill’s foundation is throwing $100 million at it — that’s a good start. Others are joining in as well. There are more than 100 vaccine-seeking research teams hard at work around the world, and probably 10% of them are onto something potentially viable. Human trials have already begun — something way ahead of the usual time-line. All of this, and much more, is worth reading on his blog.

And by the way, it bothers me greatly to hear the stupid nonsense being said about Bill Gates by the conspiracy-fuelled Covidiots whose version of reality somehow involves an evil Bill at the top of a convoluted mess of theories that make no sense at all. They’re not worth repeating, but feel free to “research” it if you want a good head-shake and laugh.

I know some people reading this know Bill Gates personally… a couple from my tech world; fellow geeks who’ve been working closely with Microsoft for decades. And from my horse world; Bill & Melinda’s daughter Jennifer is an accomplished show jumper, and the equestrian world is a small one…. so if any one of you see Bill any time soon, please tell him I say hello, and thank him for what’s he’s doing — from all of us. Of course he’ll have no idea who I am, but that’s ok — truth is, I’d like to “meet” him for a 3rd time in my life. Have his people call my people and set up a lunch, or something.

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Day 39 – April 24, 2020

Yesterday, I talked about the dinosaur apocalypse… how they were all wiped out. But, to reiterate, the only ones that were fully wiped out were the ones on the ground. As hard as it is to believe, and I know some will take exception to this… but… birds… are not descendants of dinosaurs. They are dinosaurs… the ones that survived that cataclysmic event 65… sorry, 66 million years go.

That cataclysmic event was so… umm, cataclysmic… that it wiped out 75% of all species on earth. That was fortunate for those who survived, because it gave them the evolutionary advantage to thrive, among them… mammals.

It’s a long line of evolution between those mammals and the first hominoids… but it does beg an interesting question; has the human race ever been close to extinction? Terrestrial dinosaurs were around for close to 200 million years. Humans have only been around… well, depends how you look at it. With broad brush strokes, the human animal… maybe 300,000 years… but we only began to exhibit what you might call “modern behaviour” around 100,000 years ago.

What would’ve happened if a pandemic-capable virus had shown up? Not much, because there was next to no overlap of communities distanced by geography. It makes one wonder, how often have there been these sorts of viruses over the centuries? Probably lots. But it was localized, there was no treatment, there was no social distancing… all that happened was a big wave of very sick people dying, and eventually through herd immunity and/or lots of death, the virus made its way through everyone it could, and then disappeared from existence.

But the human race actually did come close to extinction, and it wasn’t that long ago, geologically speaking. Well, this is one theory. It’s interesting, as usual, to research things on the Internet because you can always tell where the conformation bias lies. You can tell what people want to believe, and how they conform their evidence to support their side.

Around 75.000 years ago, there was a massive volcanic eruption — one of the biggest ever. The Toba Supereruption (Lake Toba, Sumatra, Indonesia) erupted and ejected some 2,800 cubic kilometres of magma. That is a staggeringly huge cube of hot, melted rock… and it left behind something the same size as the crater that took out the dinosaurs… an enormous 100 x 30 km caldera complex. Once again, it messed with the environment very significantly… the six billion tons of sulphur dioxide that were ejected into the atmosphere caused a global cooling of up to 15 degrees all around the planet for at least a few years, and it was many decades before things returned to normal. This lowered the tree line and snow line by about 10,000 feet… and for humans who were used to a dry, temperate climate, years of perpetual snow did not sit well.

There is a genetic bottleneck at the time when looking back at humans, meaning it seems we can all trace our DNA back to a small group (like a few thousand humans) who made it through that. The rest were wiped out. And to some extent, if that’s what happened, you have to assume we’ve all evolved from a pretty tough group of humans. This was survival of the fittest imposed in the harshest of ways.

This is one theory, and it’s very interesting. There is another group of scientists who claim that’s hogwash, and that the evidence doesn’t necessarily imply any of that.

Whatever the case, all of that I learned yesterday while digging into dinosaurs… you know how the internet can be… one moment you’re reading about what you were researching, like dinosaurs and their extinction… and 40 minutes later you’re reading about mentally ill monarchs throughout human history.

That’s a good little segue onto a topic I really don’t want to touch here. I had a whole thing written out, and indeed, I could write a book on my thoughts with respect to American politics of the day, but this is a scientific and statistical endeavour, ostensibly aimed at keeping track where we are with respect to this pandemic. On that note, it’s not irrelevant to point out, as I have earlier, the shortcomings I see when it comes to leadership pulling in different directions, etc etc. But I just deleted many paragraphs that delve into far more detail, and will leave it at that.

OK, one paragraph. I worry greatly for the great country of the United States of America. Every single day, thanks to the actions or words of just one man, the chasm that separates two groups (big broad brushstrokes here: Republicans and Democrats) — gets a little bigger. It started on day 1, lying about the inauguration crowd size. “Who really cares” is really what should have been the answer, but he chose to lie about it, then double down on his lies, then make others lie for him… it was bewildering, to be honest. What the hell is going on? There was incontrovertible evidence… pictures and witnesses and everyone who was there… but no. It ended up with “alternative facts” trying to be jammed down our throats. All of this on day 1 of his presidency. And since that day, whenever he says or does something that is completely unpresidential, both sides rise to the challenge. And while the argument rages on about who’s right and who’s wrong, the country slides a little bit more downhill. This is not to bash on Republicans and Democrats… there was a time when both those parties worked in harmony for the greater good of the country, especially in times of crisis. I really wonder how repairable this is now. Long after Trump is gone, the degree of bipartisanship needed to successfully guide a country — may not be achieved for many, many years. And I’m not interested in the bullshit arguments of what a great job he’s presently doing. He’s not. I don’t use vague handwaving and gut feel to come to my conclusions, I use hard facts. As you may recall, this entire project of charts and graphs and light commentary started with a simple exercise of trying to track Canada’s response to this crisis as measured by comparing the U.S. and how they were doing. And comparing them to Italy, who was ahead of them. The short answer now is: Awful. Brutal. Look at the numbers, look at the graphs. This isn’t fake news, this isn’t opinion. These are their numbers. These are confused people. These are hospitals that can’t keep up. These are states and leaders with mixed messages. These are deaths. These are the preventable disastrous blue line and its associated numbers, towering over the green, red and black ones below it. This is failed leadership, from the very top.

Sorry for the long paragraph… but I did say, just one paragraph. But, some numbers… Canada, today, flat or better growth all across the country. U.S…. more deaths today than the number of new cases in Canada. Also U.S., more deaths today than the entire number of known cases seen in B.C., active or resolved, since the beginning of this pandemic. And finally, U.S., more new cases today than all of what Canada has seen, combined, since day one. By the end of the weekend, the U.S. will have seen its one millionth case. Canada will be below 50,000. That same proportion maps to deaths. And some quick math for you… no, the population of the U.S. is not 20 times that of Canada. Not even 10. As President Trump likes to sign at the end of many of his Tweets: Sad.

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Day 38 – April 23, 2020

When I was a kid, I was taught that the dinosaurs died out sixty-five million years ago. More recently, my kids, when they were in elementary school studying dinosaurs… were taught that they died out sixty-six million years ago. How exactly did a million years elapse in less than 50? Was it at 65,999,980 in the late 70s, and it just recently “rolled” over to 66?

No… but something must have changed, and it did, from various directions. Geophysicists, geologists, palaeontologists and other researchers… all working on completely different things — some drilling for oil in the Gulf of Mexico, some working on hypotheses regarding the mass-extinction event from around 65 million years ago, some researching a very thin but fossil-diverse soil layer in New Jersey from around that time period… at some point, in the early 80s, someone asked the “what if…?” of a meteor/asteroid/comet slamming into earth might hold some explanations… and indeed, the puzzle pieces all fit. And, further to that, if that were the case, we should also be finding other things, specifically… well, this and that, and when “this and that” were searched for, they were found. Including dating that massive crater to just over 66 million years.

That crater (the Chicxulub crater — 100km wide, 30km deep) was caused by a piece of rock somewhere between 11 and 81 km in diameter, slamming into the earth with a force of somewhere around 500 billion Hiroshima A-bombs. That’s a lot of bombs… so let’s do some ridiculous math…

Each bomb is 3 metres long…. so if we line them up, end to end, that’s 1.5 billion km. That’s from earth, to the sun… and back. Five times. Or back and forth to Mars, four times. Or one, nice long line of A-bombs… from here to Saturn.

So imagine all that firepower concentrated in one spot, all blowing up at once. It’s a wonder the earth itself survived. It did, though the massive earthquakes and tsunamis and acid rain and volcanic eruptions and blocked-out sun for years… did not make for great living conditions. All of the terrestrial-based dinosaurs were wiped out, and all that’s left of them are the ones that could literally fly above disaster below. Indeed, from a dinosaur’s point of view, we are all living in a post-apocalyptic world.

And how do we know all this? Science. Knowledge attained through study and practice. Knowledge acquired through the rigours of scientific testing, which itself implies a methodology that includes proving hypotheses though experimentation, data-collection and analysis. It’s not vague hand-waving and guesswork.

Which is why it’s getting a little frustrating listening to some of the nonsense spewing out of the mouths of some politicians and business leaders from around the world. Yeah, we get it — the economy is in shambles. We need to get back to normal. Everybody is suffering. But when the vast majority of scientists agree on something, they’re probably right. And when it’s not what you want to hear, that doesn’t make them the bad guy. Listen to them. Don’t fire them. We are all suffering through this present situation, and the virus doesn’t care who you are, what your political motivations are, how much money you’re losing every day. But the virus does care about surviving…if it could think, that’s the only thing it would care about. In fact, if it could survive without causing you any bad side-effects, it’d probably choose that, because then it could propagate further and guarantee its survival. Either way, it’s not going to go away on its own… and its efforts to survive hurt us… and if we left it to run wild, we would be in a world of hurt.

Many different scientists are working on this. Not geologists nor palaeontologists. More like epidemiologists, microbiologists, immunologists, virologists and biotechnologists. And a whole host of other “…ists”. Today, they say things like “social distance” and “lockdown”, and for that, they’re the bad guys. One day, when the same people are saying, “here’s a vaccine”, they will be heroes.

They’re already heroes, thrown into a spotlight none of them ever wanted. “Leave me alone to do my research for the greater good”, they would tell you… but instead, they seem to face the wrath of those who don’t want to deal with reality because it conflicts with their electorate and/or bottom line.

Once again, and I’ve said this countless times… we’re very lucky around here. We have scientists who know what they’re talking about and we have politicians who listen to them and we have business leaders who understand the big picture. Looking around the world, we seem to be in a fortunate bubble of intelligence, harmony and cooperation… which is why if we do what they say, we will all get out of this sooner. And today is a good example; only 29 new cases here in B.C., including cases in known clusters… which means, at most, only a handful of new community cases. No jumps in hospitalizations or ICU cases. Steady as she goes.

And by the way, scientists… you managed to adjust that dinosaur number by a million years… we’ve been at this for about 4 months now… and back then, we were being told a vaccine in 12 to 18 months away. Can we adjust that a bit…? How about 8 to 14 months?

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Day 36 – April 21, 2020

The answer to the question…. “Where are you finding all this time to research and write?” — is every simple. All the time I spent driving, parking, walking… from meeting to meeting to lunch to meeting to meeting to whatever… well, when all of that travel can be measured in centimetres and the time it takes in seconds… here we are. These scribbles are the result of free time that never used to exist. Also, the length of many of these meetings now can quickly be trimmed… well, jeez darn it, looks like the WiFi is crapping out, gonna have to let you go, my people will call your people, yeah ok, bye.

I don’t do a lot of that… I’m too polite. That’s never really an option when it’s in person, but when you’re behind a screen and keyboard… it’s tempting. In any event, you can always check your brain out of a meeting, and that often happens when I’ve lost interest… which sometimes happens right off the bat. I listen to a lot of ideas and proposals, but certainly one way to get me to hang up my brain is to throw lots of buzzwords at me.

“Hey Horatio, thanks so much for taking the time to talk to me. I know you’re busy so I’ll get right to it. What our app intends to do is to disrupt the market, to shift the blockchain paradigm by leveraging existing synergies in the deep learning space and employing best practices to scale-up the mission-critical algorithms that’ll fuel the next generation of mobile.”

Dude, you’re a paragraph in, and you’ve already lost me.

And this is the same filter I’m using while trying to wade through the colossal amount of information with which we’re being bombarded these days. More than three buzzwords in one breath equals nonsense.

Self-serving, bias-conforming, buzzword-infested “reports” that magically wind up at the conclusion that perfectly aligns with the author’s intended audience, political beliefs, click-bait potential… whatever. If you want to believe that this virus was caused by reptilian aliens who’ve arrived on earth, and who’ve activated it with their nefarious 5G signals so as to expose Bill Gates’s agenda of GMO’ing vaccines because he’s just a pawn for big pharma who already have the vaccine because they’re in cahoots with the aforementioned aliens… yeah, I guess there’s not much I can say that’ll change your mind. That’s an extreme example of the crap that’s out there… but since it’s on a well-designed website with a very trustworthy-looking font… well, it might be true, right? Yeah… no… why don’t you just take that paradigm and shift it, if you know what I mean.

But once in a while, credible reports — from credible sources — arrive at similar conclusions, having started at very different points. And those are always interesting because they, unless they’re referencing each other, might offer some unbiased, independent… dare I say it… truth.

There’s this famous Stanford report that’s buzzing around these days… claiming that recently, while Santa Clara county had only 1,094 confirmed cases, antibody tests suggest that the number was somewhere between 48,000 and 81,000. The range of that number is wide enough that it makes one wonder about the inherent problems of the test sample. I have no idea, but that’s a pretty big error range. Nevertheless, let’s go with it and just pick the average… 48+81 = 129….. 129k ÷ 2 = 64,500…. and 64,500 ÷ 1,094 = 59x. If we apply a 59x factor here in B.C., that’s 59 x 1,724 cases… which is around 100,000… which is 2% of our population of 5,000,000.

Independently, the WHO have announced that they’ve found that 2% to 3% of the population they’ve tested has antibodies.

And independent of that, a study in the Netherlands of 7,000 blood donors found that 3% had antibodies.

Which brings up the discussion of one of the buzzwords-of-the-day: herd immunity.

Herd immunity is where enough people of a population are immune; immune enough that the infection will not spread within that group. The more infectious a disease, the higher that percentage has to be. For example, mumps is very contagious… Rø of 10 to 12, meaning every infected person will infect, on average, 10 to 12 others. Left unchecked, this would lead to 95% of the population getting infected. The other 5% inherit the benefit of the herd immunity that provides, because eventually there’s no one to catch it from. That herd-immunity threshold can only be reached via vaccination because allowing everyone to catch it is not an option. It’s a horrible disease, and these days, completely preventable.

For COVID-19, the Rø number is much lower… around 3, which implies a herd immunity percentage of around 70%. Which unfortunately, is well above the natural 2% to 3% that may be occurring.

Germany claims the “cases in the wild” number to be higher than that… a little over 10%. Better, but still far from what’s needed… which is a vaccine, which would launch that number into the high 90s and that would be the end of this pandemic.

Until that happens, the best thing to do is not catch this and/or give it to someone else.

BUT — and this is a big but, in two parts… IF you are already one of those 3% and IF having antibodies grants you immunity, then your individual life going forward does look a little different. For one thing, you can stop worrying about catching it.

There is no general agreement yet on how much immunity these antibodies confer, but some… for sure. What concentration you need in your blood, how long it lasts… all of that remains to be seen. I’m not sure who gets those antibody tests and when, but they’ll be arriving here in B.C….. soon. Sign me up.

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Day 33 – April 18, 2020

Did you know that the bubonic plague is still around? That pesky little bug that killed up to 200 million people in the Middle Ages still pops up from time to time. A boy in Idaho got it a couple of years ago, I kid you not.

“Hey Jimmy, what’d you do all Summer?”
“Actually, I was sick for most of it with bubonic plague”

It’s almost worth getting, just so you can bring it up in Show’n’Tell. So much better than “Visited the grandparents in Wichita and miked some cows”.

Jimmy (probably not his real name) is fine… completely cured with a routine course of modern antibiotics. Jimmy is lucky he wasn’t born 500 years ago, because his pocket full of posies would have done nothing for his ring around the rosie.

The bacteria that causes bubonic plague has been quietly around for at least 6,000 years, but every once in a while, it makes a big splash. The Black Death, which peaked in the mid-14th century, was the biggest known pandemic of that particular bug, but there have been many outbreaks over the centuries… and while they’ll never achieve the magnitude of what happened in the Middle Ages, two breakouts is 2014 and 2017 in Madagascar killed around 200 people. And it’ll keep showing up, because it’s bacteria and it’s alive.

Unlike bacteria, viruses aren’t alive in the sense that they can just procreate on their own. They need a host, and in the current case, that host is a human… and in particular, human noses and airways. That’s a relevant point, which differs, for example, from SARS, also a coronavirus… which appeared and died-off in 2003. It incubated deep in people’s lungs. There are many other differences as well. SARS was far deadlier (~10%) but also less contagious. And the biggest difference is that while COVID-19 is still around, SARS-CoV is gone… extinguished from existence, except deeply-buried is research laboratories. Extinguished because of the way it was managed; the same gameplay of testing and isolating until every known host was known, and then kept away from infecting others. No host to jump to means it dies off, and that’s that. As has been widely quoted… if we could 100% isolate everyone on the planet for 14 days (probably a little longer, but not much) and keep completely isolated those who develop symptoms in that time — this thing would be squashed out of existence. That’s impossible to achieve, so the next best thing is a vaccine, which can, in due course, achieve the same thing. Has that ever actually been done?

Yes — and it’s one of the greatest achievements of medicine. Smallpox is gone, entirely, as of 1980, after a concerted effort that took decades. Smallpox was a horrible disease, with awful symptoms and a mortality rate of 30%, and you could catch it from someone coughing or sneezing on you, or touching contaminated surfaces… the usual that we are all familiar with these days.

But back in the day, medieval epidemiologists (heh) did not have a lot at their disposal, and it’s hard to blame them. Germ theory was centuries away from being figured out. Plague doctors wore those famous plague masks with the long noses, full of good-smelling herbs… which, if they didn’t help keep them safe, at least helped mitigate the stench of dying people all around them. In fact, back then, it was thought that illness was transmitted through miasma… bad-smelling air. A kind of chicken-and-egg causality where you assume the bad smell in the air is cause of all this illness… not the result. The name “malaria” literally means “bad air” in latin. But at least to some extent they’d figured out that keeping away from sick people was a good idea; the first versions of social distancing. Those Venetian masks with the long noses? It’s hard to cough/sneeze on someone when you can’t get too close. They understood at least that: stay away. I have this image of a medieval Dr. Henry, standing at the top of the Rialto Bridge, yelling down to the gondoliers on the Grand Canal… “Hey you down there! You shouldn’t be oot and aboot! Go home!” She wouldn’t be yelling, of course… more like softly but strongly suggesting.

Germ theory eventually sorted it out, but there was an interesting little overlap of time where smallpox “vaccines” from the Far East arrived in Europe, and worked… but nobody understood why. That didn’t fit with any known medical knowledge of the time, but it seemed that taking powdered smallpox scabs and inhaling them… would lead you to develop a mild form of the disease, from which you would recover. Well, most of you. There was a 2% mortality rate with that treatment… which is still a lot better than 30% if you get it. Game-theorists of the day could have tried to figure out what gave them better odds… a certain 2% chance of death vs. a N% chance of contracting something with a 30% chance of death. Here, I’ll do the math… if you thought your chances of contracting smallpox were greater than 7% (one in 14), go for the scab inhalation. I’ve bet on enough 14-1 shots in my life to know that I should take my chances with the scabs.

I say all this because the people back then, flying blind as they were, made the best of what they had and what they knew. We are way ahead these days… but as we’re all experiencing, there’s always plenty more to learn… and I think it’s going to really heat up in the next few weeks. We have a perfect storm overlapping of emerging antibody tests, conflicting studies from around the world regarding how widespread this is, data from jurisdictions that are doing things very differently and so on. And much of this is saddled with a conformity bias that makes it very difficult to navigate. When you start with a conclusion you’re hoping to reach, it’s not difficult to find the data to support it. It’s all out there. We will navigate it as best we can.

Speaking of we — we around here, and in Canada in general, saw a good day of numbers… a line of green… everything trending nicely… for now. This week we’ll start seeing the effects, if any (and hopefully, none)… of the long weekend.

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Day 26 – April 11, 2020

For the sake this example, I’m about to virtually kill a lot of people. Please don’t feel bad — they never existed.

Let’s imagine you want to drive from Vancouver to Seattle… and let’s further imagine that there’s a winding road that follows the coastline all the way down. Sidenote — for part of it, there is… there’s a 20-mile winding road from Bellingham to Burlington called Chuckanut Drive that’s well-worth the detour. Spectacular views and much more.

So… there’s the imaginary coastline road, and there’s Highway 99/I-5 which actually exists.

And you’re a new driver, kind of nervous… the thought of the fast-moving traffic on the highway scares you a bit. But you also know the coastline road is very winding, and you’ve heard of cars losing control and going over the cliff. You do your research and quickly find a report that tells you that over the last two years, accidents killed 45 people on the highway and 24 on the coastline road. Again, I’m making this all up. Nobody was hurt in the creation of this posting.

No brainer, you think, the coastline road is twice as safe as the highway… because that’s the ultimate measure of safety, and there can’t be too much more to it…

Well, there can be… and if you keep reading down my imaginary report, you’ll find that the coastline road seems to have about one accident a month. Like clockwork, once a month, a single-occupant vehicle loses control, rolls down the 100-foot cliff and kills the driver. That accounts for the 24 deaths.

On the highway, as it turns out, some idiot last year was celebrating something… and rented out one of those monstrosity stretch Hummer limos, filled it with 43 of his closest buddies… and apparently everybody, including the driver, got drunk… and the limo, with its full tank of gas, crashed into a telephone pole, exploded into flames and killed all 45 occupants.

That changes things a bit, doesn’t it…

Those 24 single-car accidents each have a little circle around them. The HummerLimo has a single, big circle around it. Around here, the Lynn Valley Care Centre has a big circle around it too, as does the administration office of Lions Gate Hospital. The Mission Institution. The Okanagan Correctional Centre in Oliver. The Blueberry River First Nations community near Fort St. John. All of them have their own little circles.

So… let’s talk about clusters.

From an epidemiological point of view, a cluster is defined by infections that are grouped by where and when they happened. If those two things are close to each other, they’re part of the same cluster. Infections can be clustered, deaths can be clustered. Really, any statistic can (and usually should) be associated where it’s relevant.

In B.C., the Lynn Valley Care Center (where the average age of residents is 87) recorded Canada’s first COVID-19 death on March 8th. Since then, it’s accounted for an additional 17. Here in B.C., our mortality rate per resolved case is 6.0% when you count Lynn Valley, and 4.3% when you don’t. This is in no way minimizing the importance of each and every one of those people; rather, it’s just to point out where they should fit in statistically.

Treating those unfortunate 18 deaths the same as any random 18 in the city would skew things significantly; there’s clearly a lot more to learn about those 24 individuals that drove off the cliff than by analyzing the demographics of the 45 people in the limo.

This is all something to keep in mind when reading reports that tend to favour skewing data towards their intended conclusion… something I’m saying for my own benefit as much as yours, because these days I’m being bombarded with articles and reports and opinions, many of which are diametrically opposed to each other. All of them claim credible evidence. I’m trying to keep a level head, and you should too.

As for today’s numbers… well, it’s green all the way across the bottom. From a purely aesthetic point of view, that’s as good as it’ll ever get… and it’s what I consider great evidence that what we’re doing is working. Let’s keep at it, and let’s hope those people that aren’t such good listeners don’t become clusters of their own once this long-weekend is over.

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